Solid-Phase Synthesis of β-Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Asymmetric Organocatalytic Reactions of α, β-Unsaturated Cyclic Ketones

The 1,4-conjugate addition of nucleophiles to α,β-unsaturated carbonyl compounds represents one fundamental bond-forming reaction in organic synthesis. The development of effective organocatalysts for the enantioselective conjugate addition of malonate, nitroalkane and other carbon and heteroatom nucleophiles to cycloenones constitutes an important research field and has been explored in recent...

متن کامل

Organocatalytic kinetic resolution via intramolecular aldol reactions: enantioselective synthesis of both enantiomers of chiral cyclohexenones.

Kinetic resolution of 6-aryl-2,6-hexanediones was achieved with chiral secondary amine catalyzed intramolecular aldolization. The current kinetic resolution protocol enables the synthesis of both enantiomers of cyclohexenones with moderate to good enantioselectivity.

متن کامل

Organocatalytic direct asymmetric aldol reactions in water.

We have developed direct asymmetric cross-aldol reactions that can be performed in water without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl chain efficiently catalyzed the reactions and afforded the desired aldol products in excellent yield with high enantiomeric excess, even when only an equal molar ratio of the donor and acceptor was used. These result...

متن کامل

ChemInform Abstract: Direct Synthesis of β- Hydroxy-α-amino Acids via Diastereoselective Decarboxylative Aldol..

A straightforward metal-free synthesis of anti-β-hydroxy-r-amino acids is described. The organic base-mediated decarboxylative aldol reaction of cheap, readily available r-amidohemimalonates with various aldehydes afforded under very mild conditions anti-β-hydroxy-r-amido esters in high yields and complete diastereoselectivity. Simple one-pot subsequent transformations enabled the corresponding...

متن کامل

Highly Diastereoselective Aldol Reactions of Chiral Methyl Ketones

Diastereoselective aldol additions have emerged as one of the most efficient and versatile methods available for preparing a wide range of optically active compounds.l Very high diastereoselectivities have been reported for aldol reactiona involving chiral enolates derived from a-ethylor higher alkyl-substituted ketone derivatives. By contrast, relatively few examples of highly diastereoselecti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: ACS Combinatorial Science

سال: 2018

ISSN: 2156-8952,2156-8944

DOI: 10.1021/acscombsci.8b00001